Posted by: Sabio Lantz | June 2, 2009

Leptin & Lectins


In an Evolutionary Fitness diet, grains and legumes are avoided.  Below is part of the rationale.  Realize that hunter gatherers could easily get tubers for nutrition, but before the agricultural revolution, grains and legumes were neither plentiful nor easily eatable.


  • a hormone that signals satiety, or fullness.
  • secreted by fat tissue
  • thus normally causes you to eat less as you build fat
  • Zucker rats have leptin receptor (in brain) gene missing thus get fat
  • Zucker rats reproduce many diseases present in human civilization obese, hypometabolic, develop insulin resistance, impaired glucose tolerance, dyslipidemia, diabetes, and cardiovascular disease.
  • Fat people are leptin resistant (inject leptin and they are still hungry)
  • Leptin resistance precedes insulin resistance
  • Carbohydrate-loving Kitavans don’t get elevated leptins like europeans.
  • Kitvans, Kuna consume high carbohydrate but little or no grain and have low circulating leptin.


  • a molecule that specifically binds carbohydrates
  • Many plants use lectins as a defense against hungry animals
  • Grains and legumes (beans, soy, peas, peanuts) are rich in some particularly nasty lectins.
  • Some lectins degrade the intestinal lining
  • Some get into the blood and bind carbohydrate-containing proteins including the insulin receptor and possible the leptin receptor (not tested yet)
  • Soaking beans overnight breaks down leptins (grandparents did this)
  • Fermented bread dough
  • Nixtamalizing Corn
  • We don’t do these things for modern food.
  • Yams, taro, sweet potatoes, plantains, yucca, kidney beans eaten by healthy cultures but when they ate Western diets , they got fat.

Source:  Whole Health Source by Stephan Guyenet



  1. Stephan,
    Your information is solid but your credibility would be enhanced if your grammar was a lot better

  2. Well, I’m a little confused. It seems Stephan Guyenet was the source for the article but that Sabio Lanz is the site developer?
    If so, then my constructive criticism was aimed at the site-developer. This could be a good site of general interest to seekers of better health, but needs better grammar in order to gain credibility.
    I’ve been a paleo dieter and exerciser for 25 years due to long-lasting ill health and can only say that had I been exposed earlier, I’d be a lot better off today!

  3. Yes, Luigi. I don’t write recently! I wish I had time. The source, as I write, Is Guyenet. I wrote the post.

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